Health Heparin is an anticoagulant drug produced by Baxter Healthcare. Heparin sodium is used for prevent blood clotting in patients undergoing dialysis, cardiac surgeries (but only certain types) and to treat and prevent medical conditions in similar cases. It is also administered in deep venous thrombosis (DVT) and pulmonary emboli. It was found to be contaminated by over-sulfated chondroitin sulfate in 2008. This contamination resulted in sever side effects such as allergic oral swelling, nausea, vomiting, sweating, shortness of breath, etc. Some patients suffered from bleeding episodes and some even died. The U.S. Food and Drug Administration (FDA) had alerted healthcare providers of a change in USP (United States Pharmacopeia) monograph for heparin in 2009. Manufacturers were liable for shipping heparin products manufactured and tested according to the new USP monograph. It was aimed at decreasing the potential of contamination and harm due to heparin. In 2008 Baxter recalled Heparin due to the contamination problem. This contaminated lot of heparin was produced at companys China plant. The Chinese supplier was banned for import. FDA also asked the manufacturer to label the new packets of heparin according to the new USP. It was done to differentiate the new lot from the older one. FDA tried to enforce safety through highlighting following points- Both old and new heparin was allowed to be present in the market simultaneously, to ensure adequate supply. The manufacturer of Heparin was asked to differentiate new and old heparin through lot number. FDA asked healthcare practitioners to administer the doses of heparin according to potency of both new and old heparin. FDA stressed on regular PTT and ACT monitoring for potency change. FDA left the doses for clinical judgment according to patients condition. FDA requested further investigation and study regarding side effects and contamination of heparin produced by Baxter. Study found that heparin sodium made under new USP monograph has 10% less blood thinning capability. The study was targeted to understand the potency changes and its impact in clinical processes in a better way. This study was performed in 2010. Then FDA announced safety information for both patients and healthcare practitioners. It asked patients to consult a doctor before taking heparin. It asked healthcare practitioners to take care of Potency difference between old and new heparin. Rely on clinical judgment for dose determination according to the condition of the patients. Prescribe doses according to patients need on individual basis. Read and understand the heparin label carefully. Differentiate doses for pediatric use and adult use. Report any unusual occurrence or side effects. To use products from other manufacturer or other blood thinning drug when bolus dose of heparin is necessary. Avoid bolus dose, if possible Try to use lowest possible dose at a slow infusion rate Check patients for any side effect closely Consider pros and cons of heparin before giving it to a patient. FDA has tried to ensure safety of patients using heparin by regulating its production and use. Many complain lack of fund with FDA makes it difficult to monitor all the drugs effectively. For more information visit: ..unsafedrugs../fda-and-baxter-heparin/ About the Author: Whether you are trying to obtain into shape, get into much better shape or are in the finest shape of your life, you will certainly have the ability to take advantage of these fantastic physical fitness pointers which can assist you reach any physical fitness goal that you want. , … Nutrition is an essential element of everyone’s life. Nutrition includes eating and drinking correctly to maximize physical fitness of your body and enhance your overall wellness level. A terrific nutrition suggestion is to eat numerous smaller meals throughout the day rather than … Dropping weight is not instantaneous, as if you wished on a magic lamp. While we reside in a culture where we anticipate fast, like fast food that’s all set in 5 minutes, losing 10 pounds does not fit in this category. Before you begin a weight management plan, you have to … Have you’ve made a strong and scary decision to lose 10 pounds and you’re doing it for better wellness and more confidence … both you can obtain from dropping additional weight. You must likewise take a look at your workout routine to assist you lose 10 pounds. Possibly you made … Whether you are trying to obtain into shape, enter much better shape or are in the finest shape of your life, you will certainly be able to gain from these great fitness ideas which can help you reach any fitness goal that you have in mind. If you really desire to get wonderful loo … 相关的主题文章:

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